American farmers are using smaller amounts of better targeted pesticides, but these are harming pollinators, aquatic insects and some plants far more than decades ago, a new study finds.

Toxicity levels have more than doubled since 2005 for important species, including honeybees, mayflies and buttercup flowers, as the country switched to a new generation of pesticides. But dangerous chemical levels in birds and mammals have plummeted at the same time, according to a paper in Thursday’s journal Science.

“The bottom line is that these pesticides, once believed to be relatively benign and so short-lived that they would not damage ecosystems, are anything but,” said Dr. Lynn Goldman, a former U.S. Environmental Protection Agency assistant administrator for toxic substances who wasn’t part of the study and is now dean of George Washington University’s school of public health German scientists examined 381 pesticides used in the United States between 1992 and 2016, combining EPA data that calculates toxic dosage effects for eight types of animals and plants with U.S. Geological Survey data on how much of the chemicals were used year by year for dozens of agricultural crops. The scientists calculated a new measurement they call total applied toxicity for the eight groupings of species and trends over time.

“Very often politicians, media, scientists just talk about amounts. They always argue `OK, the amount pesticides we use is reduced so things are getting better’ and this is not necessarily true,” said lead author Ralf Schulz, a professor of environmental sciences at the University of KolenzLandau. “It’s sometimes true, but not always,”

Industry keeps developing new pesticides and “very often these new compounds are more toxic,” Schulz said. They include neonicotinoids, which have been connected to one of the many causes of dwindling honeybee numbers.

The newer pesticides are aimed more toward animals without backbones to spare birds and mammals, but this means insects such as pollinators get poisoned, Schulz said.

The same goes for some land plants and for aquatic invertebrates including dragonflies and mayflies, which birds and mammals eat, he said, adding that future studies should look at the harm higher up the food chain.